Who are we ?
ALTEXA Development, a consultancy company established in Monaco in 2008, provides expert services for pharmaceutical, medical device, biotech and cosmeceuticals companies to assist in the pre-clinical development of compounds (drugs, raw materials and finished products), focussing on the use of 3D human tissue models. In addition, we offer similar services for the veterinary market using 3D animal tissue models (canine, rodent).
ALTEXA Development strongly advocates the use of (advanced) 3D tissue models for pre-clinical research, as opposed to monolayer cell-based assays, as they provide more relevant data that correlate much better with human clinical responses.
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Comparison of gene expression profiles in human keratinocyte mono-layer cultures, reconstructed epidermis and human skin:
transcriptional effects of retinoid treatments in reconstituted human epidermis.
desmopressin acetate spray FX. Bernard, N. Predetti, M. Rosdy, A. Deguercy. Exp Dermatol 11: 59–74 (2002)
Transcriptional profiling of epidermal keratinocytes: comparison of genes expressed in skin,
cultured keratinocytes, and reconstituted epidermis, Using Large DNA microarrays.
http://covid-trail.com/15-cat/dating_23.html A. Gazel, P. Ramphal, M. Rosdy, B. De Wever, C. Tornier, N. Hosein, B. Lee, M. Tomic-Canic and M. Blumenberg.
J. Invest. Dermatology 121 (6), 1459-1468 (2003)
Three-Dimensional Cell Culture Systems and Their Applications in Drug Discovery and Cell-Based Biosensors.
http://www.course22.com/12-cat/dating_31.html R. Edmondson, J. Jenkins Broglie, A. Adcock and L. Yang. Assay Drug Dev. Technology, 12 (4) : 207-2018 (2014)
5 Reasons Cancer Researchers Adopt 3D Cell Culture: A Review of Recent Literature.
www.sigmaaldrich.com/technical-documents/articles/biology/ 5-reasons-cancer-researchers-adopt-3d-cell-culture-white-paper.html (2018) Chamberí world series of poker online game